Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | APLNR | P35414 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15878428 | 0.81 | TAS1R3 (0.52) | KDM4CMAPTHTR2AHTR2CAPLNR | |
| SCHEMBL22556655 | 0.75 | APLNR (0.65) | HTR2AHTR2CAPLNRTAS1R3TAS1R1 | |
| SCHEMBL16343541 | 0.73 | KDM4C (0.64) | KDM4CMAPTAPLNRTAS1R3TAS1R1 | |
| SCHEMBL1493653 | 0.73 | MAPT (0.59) | KDM4CMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3200678 | 0.73 | APLNR (0.67) | KDM4CHTR2AHTR2CAPLNRTAS1R3 | |
| SCHEMBL20565881 | 0.73 | APLNR (0.61) | HTR2AHTR2CAPLNRTAS1R3TAS1R1 | |
| SCHEMBL22657816 | 0.73 | APLNR (0.66) | KDM4CMAPTAPLNRTAS1R3TAS1R1 | |
| SCHEMBL29444046 | 0.73 | APLNR (0.66) | KDM4CMAPTAPLNRTAS1R3TAS1R1 | |
| SCHEMBL7768853 | 0.72 | APLNR (0.86) | HTR2AHTR2CAPLNRMEN1KMT2A | |
| SCHEMBL701192 | 0.72 | TAS1R3 (0.86) | MAPTAPLNRTAS1R3TAS1R1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016106628-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | WO | disclosed |