Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17896058 | 0.99 | LMNA (0.32) | LMNAUSP2ALDH1A1POLBAPEX1 | |
| SCHEMBL17896150 | 0.87 | LMNA (0.30) | LMNA | |
| Hydrochloric Acid SCHEMBL17896042 | 0.86 | — | — | |
| SCHEMBL17895831 | 0.86 | LMNA (0.36) | LMNAUSP2ALDH1A1POLBAPEX1 | |
| Hydrochloric Acid SCHEMBL17895824 | 0.85 | LMNA (0.35) | LMNAUSP2ALDH1A1POLBKDM4E | |
| SCHEMBL17896059 | 0.82 | ALDH1A1 (0.36) | LMNAUSP2ALDH1A1POLBAPEX1 | |
| Hydrochloric Acid SCHEMBL17895933 | 0.81 | ALDH1A1 (0.35) | LMNAUSP2ALDH1A1POLBAPEX1 | |
| SCHEMBL17896004 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL17896091 | 0.78 | — | — | |
| SCHEMBL17896099 | 0.78 | PDE5A (0.42) | LMNAALDH1A1POLBKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | claimed |
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |