Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | LDHB | P07195 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896006 | 0.85 | LMNA (0.38) | LMNAUSP2PKMSPRTSHR | |
| SCHEMBL17895874 | 0.84 | LMNA (0.37) | LMNAUSP2PKMPTK2LDHA | |
| SCHEMBL17895862 | 0.79 | KMT2A (0.40) | LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL17895823 | 0.79 | LMNA (0.35) | LMNAUSP2PKMLDHALDHB | |
| SCHEMBL17895978 | 0.78 | LMNA (0.34) | LMNAUSP2PKMSPRTSHR | |
| SCHEMBL17895939 | 0.75 | PARP1 (0.36) | LMNAUSP2PKMSPRTSHR | |
| SCHEMBL17895839 | 0.73 | PLK1 (0.47) | LMNAUSP2PKMSPRTSHR | |
| SCHEMBL17896031 | 0.73 | FABP4 (0.34) | KDM4EALDH1A1MAPT | |
| SCHEMBL17896079 | 0.73 | LMNA (0.35) | LMNAUSP2PKMTSHRKDM4E | |
| Hydrochloric Acid SCHEMBL17896043 | 0.72 | FABP4 (0.34) | LMNAKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | claimed |
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |