Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17895978 | 0.79 | LMNA (0.34) | PARP1LMNAUSP2SPRPOLB | |
| SCHEMBL17895874 | 0.78 | LMNA (0.37) | LMNAUSP2SPRPOLBMAPT | |
| SCHEMBL17896050 | 0.75 | LMNA (0.36) | PARP1LMNAUSP2SPRPOLB | |
| SCHEMBL17896049 | 0.75 | LMNA (0.35) | LMNAUSP2SPRPOLBMAPT | |
| SCHEMBL17895779 | 0.74 | LMNA (0.34) | LMNAUSP2SPRMAPTTDP1 | |
| SCHEMBL17895839 | 0.74 | PLK1 (0.47) | PARP1LMNAUSP2SPRMAPT | |
| SCHEMBL17895985 | 0.74 | DRD2 (0.43) | PARP1LMNAUSP2SPRMAPT | |
| SCHEMBL17896079 | 0.74 | LMNA (0.35) | LMNAUSP2POLBMAPTTDP1 | |
| SCHEMBL17896153 | 0.74 | LMNA (0.37) | LMNAUSP2SPRPOLBMAPT | |
| SCHEMBL17895899 | 0.74 | LMNA (0.33) | LMNAUSP2SPRMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | claimed |
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |