Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 10/20 | 0.67 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.67 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL432104 | 0.84 | PDE10A (0.65) | CYP11B2CYP11B1PDE10APOLBSMN1; SMN2 | |
| SCHEMBL17896603 | 0.82 | CYP11B2 (0.53) | CYP11B2CYP11B1POLBSMN1; SMN2ALOX15 | |
| SCHEMBL10175597 | 0.80 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP3A4 | |
| SCHEMBL10175358 | 0.79 | PDE10A (0.65) | CYP11B2CYP11B1PDE10APOLBSMN1; SMN2 | |
| SCHEMBL17896729 | 0.79 | PDE10A (0.46) | CYP11B2CYP11B1PDE10APOLBSMN1; SMN2 | |
| SCHEMBL17896604 | 0.78 | PDE10A (0.53) | CYP11B2CYP11B1PDE10APOLBSMN1; SMN2 | |
| SCHEMBL10176202 | 0.77 | CYP11B2 (0.73) | CYP11B2CYP11B1HTTATM | |
| SCHEMBL461417 | 0.77 | PDE10A (0.46) | CYP11B2CYP11B1PDE10APDE2A | |
| SCHEMBL17896741 | 0.77 | CYP11B2 (0.47) | CYP11B2CYP11B1PDE10APOLBSMN1; SMN2 | |
| SCHEMBL17896744 | 0.77 | CYP11B2 (0.47) | CYP11B2CYP11B1POLBSMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |