Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.72 |
| ▸ | RXRB | P28702 | 3/20 | 0.72 |
| ▸ | RXRG | P48443 | 2/20 | 0.72 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | POLQ | O75417 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20575945 | 0.88 | RXRA (0.57) | RXRARXRBRXRGNR1H4AGBL2 | |
| SCHEMBL30120956 | 0.88 | RXRA (0.57) | RXRARXRBRXRGNR1H4AGBL2 | |
| SCHEMBL14060046 | 0.86 | RXRA (0.55) | RXRARXRBRXRGNR1H4AGBL2 | |
| SCHEMBL8566067 | 0.84 | RXRA (0.54) | RXRARXRBRXRGNR1H4AGBL2 | |
| SCHEMBL8580573 | 0.84 | RXRA (0.71) | RXRARXRBRXRGNR1H4NPSR1 | |
| SCHEMBL3135089 | 0.84 | RXRA (0.53) | RXRARXRBRXRGAGBL2POLQ | |
| SCHEMBL30716953 | 0.82 | POLQ (0.61) | RXRARXRBRXRGPOLQPSEN1 | |
| SCHEMBL3741058 | 0.82 | POLQ (0.61) | RXRARXRBRXRGPOLQPSEN1 | |
| SCHEMBL512428 | 0.82 | IDO1 (0.51) | RXRARXRBRXRGAGBL2POLQ | |
| SCHEMBL30530542 | 0.82 | IDO1 (0.51) | RXRARXRBRXRGAGBL2POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072156-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| US-20160193191-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160193191-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CCR1, CCR3, CCR2 | RXRA 263/4885RXRB 250/4885RXRG 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.