Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19472038 | 0.89 | LMNA (0.55) | LMNAMAPTHPGDRECQLPKM | |
| SCHEMBL15818959 | 0.86 | LMNA (0.72) | LMNAMAPTHPGDRECQLPKM | |
| SCHEMBL17899608 | 0.86 | PKM (0.50) | LMNAMAPTPKMTDP1HDAC3 | |
| SCHEMBL17899618 | 0.86 | HDAC1 (0.46) | MAPTPKMHDAC3HDAC4HDAC1 | |
| SCHEMBL17899611 | 0.85 | LMNA (0.49) | LMNAHDAC3HDAC1HDAC11HDAC8 | |
| SCHEMBL17899600 | 0.85 | KMT2A (0.56) | MAPTPKMHDAC1MEN1KMT2A | |
| SCHEMBL17899616 | 0.85 | HDAC6 (0.47) | LMNAMAPTHPGDRECQLTDP1 | |
| SCHEMBL17899621 | 0.85 | AKR1C3 (0.47) | LMNAMAPTHPGDRECQLPKM | |
| SCHEMBL17899617 | 0.84 | KMT2A (0.58) | LMNAMAPTPKMMEN1KMT2A | |
| SCHEMBL17899620 | 0.84 | HDAC1 (0.50) | LMNAMAPTHPGDRECQLPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266489-B2 | Pyrrolic amide compound and preparation method and application thereof | HITGEN LTD (CN) | 2019-04-23 | — | — | US | disclosed |
| US-10266489-B2 | Pyrrolic amide compound and preparation method and application thereof | HITGEN LTD (CN) | 2019-04-23 | — | — | US | disclosed |
| EP-3241823-B1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | HITGEN LTD (CN) | 2019-04-17 | — | — | EP | disclosed |
| EP-3241823-B1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | HITGEN LTD (CN) | 2019-04-17 | — | — | EP | disclosed |
| EP-3241823-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Hitgen Ltd. (CN) | 2017-11-08 | — | — | EP | disclosed |
| EP-3241823-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Hitgen Ltd. (CN) | 2017-11-08 | — | — | EP | disclosed |
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HITGEN INC. (CN) | 2017-10-19 | — | — | US | disclosed |
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HITGEN INC. (CN) | 2017-10-19 | — | — | US | disclosed |
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HITGEN INC. (CN) | 2017-10-19 | — | — | US | disclosed |
| WO-2016107544-A1 | INTERMEDIATE COMPOUND FOR PREPARING PYRROLE AMIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
| WO-2016107227-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HDAC1, HDAC3, HDAC11 | LMNA 1827/4885MAPT 3879/4885HPGD 520/4885 |
| US-10266489-B2 | Pyrrolic amide compound and preparation method and application thereof | HDAC1, HDAC3, HDAC11 | LMNA 1827/4885MAPT 3879/4885HPGD 520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.