Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19472030 | 0.93 | CA2 (0.49) | CA2GAAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL19559856 | 0.88 | CA2 (0.50) | CA2GAAHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL17899621 | 0.87 | AKR1C3 (0.47) | HDAC6ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL19472037 | 0.86 | AKR1C3 (0.46) | GAAHTTALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL17899605 | 0.85 | LMNA (0.55) | HDAC6HDAC2HDAC8TDP1LMNA | |
| SCHEMBL17899611 | 0.85 | LMNA (0.49) | HDAC6HDAC8GAAALDH1A1LMNA | |
| SCHEMBL17899608 | 0.83 | PKM (0.50) | HDAC6HDAC2HDAC8GAAALDH1A1 | |
| SCHEMBL19472038 | 0.83 | LMNA (0.55) | HTTALDH1A1TDP1LMNAMAPT | |
| SCHEMBL17899618 | 0.82 | HDAC1 (0.46) | HDAC6HDAC2HDAC8ALDH1A1SMN1; SMN2 | |
| SCHEMBL17899600 | 0.82 | KMT2A (0.56) | GAAHTTALDH1A1MAPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266489-B2 | Pyrrolic amide compound and preparation method and application thereof | HITGEN LTD (CN) | 2019-04-23 | — | — | US | disclosed |
| US-10266489-B2 | Pyrrolic amide compound and preparation method and application thereof | HITGEN LTD (CN) | 2019-04-23 | — | — | US | disclosed |
| EP-3241823-B1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | HITGEN LTD (CN) | 2019-04-17 | — | — | EP | disclosed |
| EP-3241823-B1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | HITGEN LTD (CN) | 2019-04-17 | — | — | EP | disclosed |
| EP-3241823-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Hitgen Ltd. (CN) | 2017-11-08 | — | — | EP | disclosed |
| EP-3241823-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | Hitgen Ltd. (CN) | 2017-11-08 | — | — | EP | disclosed |
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HITGEN INC. (CN) | 2017-10-19 | — | — | US | disclosed |
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HITGEN INC. (CN) | 2017-10-19 | — | — | US | disclosed |
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HITGEN INC. (CN) | 2017-10-19 | — | — | US | disclosed |
| WO-2016107227-A1 | PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
| WO-2016107544-A1 | INTERMEDIATE COMPOUND FOR PREPARING PYRROLE AMIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF | 成都先导药物开发有限公司 | 2016-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298016-A1 | PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | HDAC1, HDAC3, HDAC11 | HDAC6 5/4885HDAC2 4/4885HDAC8 11/4885 |
| US-10266489-B2 | Pyrrolic amide compound and preparation method and application thereof | HDAC1, HDAC3, HDAC11 | HDAC6 5/4885HDAC2 4/4885HDAC8 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.