SCHEMBL17900016

SCHEMBL17900016

c1ccc(-c2nc(-c3ccccc3)nc(C3(c4ccc(N(c5ccccc5)c5ccccc5)cc4)c4ccccc4Sc4ccccc43)n2)cc1

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
PDE5A O76074 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17893795 0.85 MEN1 (0.41) L3MBTL1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL17899961 0.84 L3MBTL1 (0.37) L3MBTL1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL17899967 0.82 MAPT (0.41) L3MBTL1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL21732802 0.81 L3MBTL1 (0.39) L3MBTL1KDM4EALDH1A1MAPTTDP1
SCHEMBL22169981 0.80 MAPT (0.38) L3MBTL1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL17899998 0.80 KCNA3 (0.33) L3MBTL1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL23028807 0.80 APP (0.35) L3MBTL1KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL21732545 0.79 L3MBTL1 (0.38) L3MBTL1KDM4EALDH1A1CYP3A4MAPT
SCHEMBL23028813 0.79 L3MBTL1 (0.38) L3MBTL1KDM4EALDH1A1MAPTMEN1
SCHEMBL17899984 0.79 ADAMTS5 (0.33) L3MBTL1KDM4EALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10329483-B2 Fluorene derivatives as light emitting elements for electroluminescent devices DOW GLOBAL TECHNOLOGIES LLC (US) 2019-06-25 US disclosed
US-20180002597-A1 Fluorene Derivatives as Light Emitting Elements for Electroluminescent Devices U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2018-01-04 US disclosed
WO-2016109274-A1 FLUORENE DERIVATIVES AS LIGHT EMITTING ELEMENTS FOR ELECTROLUMINESCENT DEVICES DOW GLOBAL TECHNOLOGIES LLC (US) 2016-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10329483-B2 Fluorene derivatives as light emitting elements for electroluminescent devices LEF1, AFF2, CELF2 L3MBTL1 1076/4885KDM4E 3225/4885ALDH1A1 520/4885
US-20180002597-A1 Fluorene Derivatives as Light Emitting Elements for Electroluminescent Devices LEF1, AFF2, CELF2 L3MBTL1 1076/4885KDM4E 3225/4885ALDH1A1 520/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.