Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.65 |
| ▸ | CTSS | P25774 | 5/20 | 0.58 |
| ▸ | CTSK | P43235 | 4/20 | 0.58 |
| ▸ | CTSB | P07858 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324443 | 0.93 | ACE (0.67) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL11277291 | 0.87 | ACE (0.61) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL10376903 | 0.85 | ACE (0.67) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL7329244 | 0.85 | ACE (0.67) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL10536264 | 0.85 | ACE (0.70) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL2603668 | 0.85 | ACE (0.70) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL17688687 | 0.85 | ACE (0.70) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL7301113 | 0.84 | ACE (0.65) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL795685 | 0.83 | ACE (0.79) | ACECTSSCTSKCTSBCTSL | |
| SCHEMBL21473784 | 0.83 | ACE (0.79) | ACECTSSCTSKCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951834-B2 | Angiotensin I-converting enzyme (ACE) inhibitors | UNIVERSITY OF CAPE TOWN (ZA) | 2011-05-31 | — | — | US | disclosed |
| US-20090281160-A1 | Angiotensin I-converting enzyme (ace) inhibitors | ANGIODESIGN (UK) LIMITED (GB) | 2009-11-12 | — | — | US | disclosed |
| EP-1893633-A2 | ANGIOTENSIN I - CONVERTING ENZYME (ACE) INHIBITORS | University of Cape Town (ZA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006126086-A2 | ANGIOTENSIN I - CONVERTING ENZYME (ACE) INHIBITORS | UNIVERSITY OF CAPE TOWN (ZA) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281160-A1 | Angiotensin I-converting enzyme (ace) inhibitors | ACE, ACE2, REN | ACE 1/4885CTSS 172/4885CTSK 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.