Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 12/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907981 | 0.88 | KDM4E (0.39) | — | |
| SCHEMBL17907954 | 0.84 | NR1H2 (0.36) | — | |
| SCHEMBL17907924 | 0.83 | NR1H2 (0.35) | GPR119 | |
| SCHEMBL17907949 | 0.82 | GABRA1 (0.35) | — | |
| SCHEMBL3542987 | 0.81 | NOTUM (0.40) | — | |
| SCHEMBL17907968 | 0.78 | HDAC1 (0.34) | GPR119 | |
| SCHEMBL17907950 | 0.78 | MAPK1 (0.33) | — | |
| SCHEMBL13279458 | 0.76 | CCR9 (0.34) | — | |
| SCHEMBL1770176 | 0.70 | KDM4E (0.34) | GPR119 | |
| SCHEMBL17907935 | 0.67 | MAOA (0.36) | PIM1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |