Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907955 | 1.00 | PIN1 (0.55) | PIN1DAOFLT3PDGFRBPDGFRA | |
| SCHEMBL5829213 | 0.82 | PDGFRB (0.57) | FLT3PDGFRBPDGFRAPOLBRAB9A | |
| SCHEMBL5829214 | 0.82 | PDGFRB (0.57) | FLT3PDGFRBPDGFRAPOLBRAB9A | |
| SCHEMBL17908002 | 0.81 | F7 (0.55) | DAOFLT3RAB9AKDM4EALDH1A1 | |
| SCHEMBL17907980 | 0.81 | KDM4E (0.55) | DAOFLT3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL17908005 | 0.81 | F7 (0.55) | DAOFLT3RAB9AKDM4EALDH1A1 | |
| SCHEMBL17907978 | 0.81 | KDM4E (0.55) | DAOFLT3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL30640889 | 0.79 | CYP2A6 (0.58) | DAOFLT3RAB9AKDM4EHSD17B10 | |
| SCHEMBL29455098 | 0.79 | CYP2A6 (0.58) | DAOFLT3RAB9AKDM4EHSD17B10 | |
| SCHEMBL245110 | 0.79 | CYP2A6 (0.58) | DAOFLT3RAB9AKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |