Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.55 |
| ▸ | F3 | P13726 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17908002 | 1.00 | F7 (0.55) | F7F3MEN1NPC1RAB9A | |
| SCHEMBL15466243 | 0.88 | ALOX15 (0.50) | F7F3DAOFLT3MAPT | |
| SCHEMBL15466242 | 0.88 | ALOX15 (0.50) | F7F3DAOFLT3MAPT | |
| SCHEMBL17907980 | 0.81 | KDM4E (0.55) | DAOFLT3KDM4EALDH1A1LMNA | |
| SCHEMBL17907978 | 0.81 | KDM4E (0.55) | DAOFLT3KDM4EALDH1A1LMNA | |
| SCHEMBL17907955 | 0.81 | PIN1 (0.55) | NPC1RAB9ADAOFLT3SMN1; SMN2 | |
| SCHEMBL17907958 | 0.81 | PIN1 (0.55) | NPC1RAB9ADAOFLT3SMN1; SMN2 | |
| SCHEMBL6295560 | 0.81 | ATP6AP1 (0.53) | KDM4ELMNA | |
| SCHEMBL6295563 | 0.81 | ATP6AP1 (0.53) | KDM4ELMNA | |
| SCHEMBL5829213 | 0.79 | PDGFRB (0.57) | MEN1NPC1RAB9AKMT2AFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |