Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 6/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KCNA6 | P17658 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | KCNA4 | P22459 | 1/20 | 0.42 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907980 | 1.00 | KDM4E (0.55) | KDM4EPDPK1ALDH1A1LMNAHPGD | |
| SCHEMBL15466232 | 0.88 | TDO2 (0.52) | KDM4EPDPK1ALDH1A1LMNAHPGD | |
| SCHEMBL15466233 | 0.88 | TDO2 (0.52) | KDM4EPDPK1ALDH1A1LMNAHPGD | |
| SCHEMBL17907958 | 0.81 | PIN1 (0.55) | KDM4EALDH1A1HPGDHSD17B10DAO | |
| SCHEMBL17908002 | 0.81 | F7 (0.55) | KDM4EALDH1A1LMNADAOFLT3 | |
| SCHEMBL17908005 | 0.81 | F7 (0.55) | KDM4EALDH1A1LMNADAOFLT3 | |
| SCHEMBL17907955 | 0.81 | PIN1 (0.55) | KDM4EALDH1A1HPGDHSD17B10DAO | |
| SCHEMBL5829214 | 0.79 | PDGFRB (0.57) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL5829213 | 0.79 | PDGFRB (0.57) | KDM4EALDH1A1LMNAHPGDTSHR | |
| SCHEMBL245110 | 0.79 | CYP2A6 (0.58) | KDM4EHPGDCYP2C19HSD17B10DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |