Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 9/20 | 0.48 |
| ▸ | ACHE | P22303 | 9/20 | 0.48 |
| ▸ | BACE1 | P56817 | 9/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907977 | 0.91 | CCR3 (0.50) | CCR3BCHEACHEBACE1GRIN2B | |
| SCHEMBL13279646 | 0.87 | GRIN2B (0.49) | BCHEACHEBACE1GRIN2BDRD2 | |
| SCHEMBL17907942 | 0.86 | BCHE (0.49) | CCR3BCHEACHEBACE1GRIN2B | |
| SCHEMBL17907992 | 0.86 | ACHE (0.48) | BCHEACHEBACE1GRIN2B | |
| SCHEMBL17908001 | 0.83 | MAOA (0.47) | BCHEACHEBACE1GRIN2BDRD2 | |
| SCHEMBL17907961 | 0.83 | BCHE (0.53) | CCR3BCHEACHEBACE1GRIN2B | |
| SCHEMBL17907991 | 0.79 | BCHE (0.49) | CCR3BCHEACHEBACE1GRIN2B | |
| SCHEMBL17907999 | 0.79 | BCHE (0.51) | CCR3BCHEACHEBACE1GRIN2B | |
| SCHEMBL17907957 | 0.75 | CYP2D6 (0.42) | CCR3GRIN2B | |
| SCHEMBL12347570 | 0.69 | TBXA2R (0.55) | CCR3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |