Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.40 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31401027 | 0.87 | CDC25B (0.45) | EGLN1SRD5A2CDC25BALKBH2ALKBH3 | |
| SCHEMBL4639489 | 0.85 | HSD11B1 (0.44) | ABCB11PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL9018690 | 0.79 | CDC25B (0.44) | EGLN1CDC25BPOLBPKMMEN1 | |
| SCHEMBL5405584 | 0.78 | CDC25B (0.53) | CDC25BPOLBPKMKMT2A | |
| SCHEMBL25316229 | 0.77 | PIK3CD (0.43) | ABCB11PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL8780064 | 0.77 | HTT (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGCDC25B | |
| SCHEMBL4597784 | 0.77 | LMNA (0.51) | EGLN1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29499772 | 0.77 | LMNA (0.51) | EGLN1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL31325736 | 0.77 | HTT (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGCDC25B | |
| SCHEMBL6298331 | 0.77 | RARB (0.46) | SRD5A2POLBP4HBRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595989-B1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2016-07-13 | — | — | EP | disclosed |