Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 10/20 | 0.60 |
| ▸ | HRH1 | P35367 | 10/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787363 | 0.88 | TSHR (0.61) | ADRA1AHRH1ADRA1BHRH3LMNA | |
| SCHEMBL13720704 | 0.84 | MEN1 (0.50) | SMN1; SMN2TSHR | |
| SCHEMBL13721057 | 0.83 | ADRA1A (0.44) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2819033 | 0.81 | ADRA1A (0.72) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL1790428 | 0.74 | ADRA1A (0.51) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2819044 | 0.74 | ADRA1A (0.66) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL30795062 | 0.74 | ADRA1A (0.51) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL1789226 | 0.74 | NPSR1 (0.64) | LMNACYP2D6CYP3A4 | |
| SCHEMBL2990937 | 0.73 | ABCB1 (0.92) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL13890824 | 0.73 | HRH1 (0.72) | ADRA1AHRH1ADRA1BHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629143-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2014-01-14 | — | — | US | disclosed |
| EP-2504317-A1 | POTASSIUM CHANNEL MODULATORS | Abbott Laboratories (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011066168-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2011-06-03 | — | — | WO | disclosed |
| US-20110124642-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124642-A1 | POTASSIUM CHANNEL MODULATORS | KCNQ1, KCNQ2, KCNQ3 | ADRA1A 260/4885HRH1 597/4885ADRA1B 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.