Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.92 |
| ▸ | ADRA1A | P35348 | 15/20 | 0.74 |
| ▸ | HRH1 | P35367 | 15/20 | 0.74 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.74 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.69 |
| ▸ | HTR2A | P28223 | 2/20 | 0.69 |
| ▸ | DRD3 | P35462 | 2/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desmethylazelastine SCHEMBL2820100 | 0.96 | ABCB1 (1.00) | ABCB1ADRA1AHRH1ADRA1BHRH3 | |
| Desmethylazelastine SCHEMBL31427639 | 0.96 | ABCB1 (1.00) | ABCB1ADRA1AHRH1ADRA1BHRH3 | |
| Desmethylazelastine SCHEMBL10561389 | 0.95 | ABCB1 (0.98) | ABCB1ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL10762965 | 0.88 | ABCB1 (0.73) | ABCB1ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL10764377 | 0.84 | ABCB1 (0.81) | ABCB1ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL10555870 | 0.84 | ABCB1 (0.81) | ABCB1ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL10552975 | 0.84 | ABCB1 (0.80) | ABCB1ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL2738787 | 0.84 | ABCB1 (0.80) | ABCB1ADRA1AHRH1ADRA1BHRH3 | |
| Azelastine SCHEMBL17803891 | 0.81 | ADRA1A (1.00) | ABCB1ADRA1AHRH1ADRA1BHRH3 | |
| Azelastine SCHEMBL4240 | 0.81 | ADRA1A (1.00) | ABCB1ADRA1AHRH1ADRA1BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184770-A1 | COMPOUNDS | GLAXO GROUP LIMITED | 2010-07-22 | — | — | US | disclosed |
| US-20100184770-A1 | COMPOUNDS | GLAXO GROUP LIMITED | 2010-07-22 | — | — | US | disclosed |
| US-20100184770-A1 | COMPOUNDS | GLAXO GROUP LIMITED | 2010-07-22 | — | — | US | disclosed |
| EP-2091538-B1 | 4-BENZYL-1(2H)-PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-03-03 | — | — | EP | disclosed |
| EP-2091538-B1 | 4-BENZYL-1(2H)-PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-03-03 | — | — | EP | disclosed |
| EP-2091538-A2 | 4-BENZYL-L(2H)-PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008074803-A2 | 4-BENZYL-L ( 2H) -PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008074803-A2 | 4-BENZYL-L ( 2H) -PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184770-A1 | COMPOUNDS | CMA1, TSLP, IL5 | ABCB1 285/4885ADRA1A 592/4885HRH1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.