Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 11/20 | 0.66 |
| ▸ | HRH1 | P35367 | 11/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2430493 | 0.83 | HRH1 (0.74) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2819033 | 0.83 | ADRA1A (0.72) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL13890824 | 0.78 | HRH1 (0.72) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2429871 | 0.77 | HRH1 (0.64) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2436781 | 0.75 | ADRA1A (0.73) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL1790852 | 0.74 | ADRA1A (0.60) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL13266215 | 0.71 | ADRA1A (0.71) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL18669052 | 0.70 | CASP3 (0.65) | ADRA1AADRA1BKDM4EALDH1A1 | |
| SCHEMBL2429351 | 0.70 | ADRA1A (0.66) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL4791221 | 0.70 | ADRA1A (0.66) | ADRA1AHRH1ADRA1BHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007735-B1 | 2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-10-27 | — | — | EP | disclosed |
| US-20090105225-A1 | 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | US | disclosed |
| US-20080039444-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039444-A1 | COMPOUNDS | CMA1, MRGPRX2, HRH2 | ADRA1A 362/4885HRH1 4/4885ADRA1B 308/4885 |
| US-20090105225-A1 | 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists | HRH2, HRH3, HRH4 | ADRA1A 150/4885HRH1 4/4885ADRA1B 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.