SCHEMBL17922015

SCHEMBL17922015

COC1=C(C(=O)C2NC=C(Cc3ccc(F)c(C)c3)S2)CN(C)C1=S

nearest known ligand 0.31

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DRD4 P21917 1/20 0.31
TMEM97 Q5BJF2 1/20 0.31
SIGMAR1 Q99720 1/20 0.31
PARP1 P09874 1/20 0.31
GRM2 Q14416 1/20 0.30
GRM3 Q14832 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14259598 0.57 LIPG (0.41)
SCHEMBL17971122 0.57 ESR1 (0.54)
SCHEMBL2094298 0.55 DRD4 (0.42) DRD4TMEM97SIGMAR1GRM2GRM3
SCHEMBL23428853 0.54 CALM1 (0.48)
SCHEMBL8259904 0.53 MMP13 (0.59)
SCHEMBL1255726 0.53 PTPN1 (0.46)
SCHEMBL12993418 0.53 SLC6A2 (0.45) DRD4TMEM97SIGMAR1
SCHEMBL14207934 0.52 MMP13 (0.48) GRM2GRM3
SCHEMBL1699671 0.52 KDM4E (0.50)
SCHEMBL23927463 0.52 MMP13 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3042894-A1 ANTIVIRAL AGENT SHIONOGI & CO., LTD. (JP) 2016-07-13 EP disclosed