Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1792203 | 1.00 | CHRNA7 (0.56) | CHRNA7MAPTTP53POLBKCNH2 | |
| SCHEMBL928080 | 0.92 | CHRNA7 (0.62) | CHRNA7MAPTTP53POLBKCNH2 | |
| Fumaric Acid SCHEMBL1793774 | 0.90 | CHRNA7 (0.53) | CHRNA7MAPTTP53POLBKCNH2 | |
| Fumaric Acid SCHEMBL1793769 | 0.90 | CHRNA7 (0.53) | CHRNA7MAPTTP53POLBKCNH2 | |
| Fumaric Acid SCHEMBL1792204 | 0.82 | MAPT (0.40) | CHRNA7MAPTTP53POLBLMNA | |
| Fumaric Acid SCHEMBL1794445 | 0.82 | CHRNA7 (0.60) | CHRNA7KCNH2HTR3ACHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL1794448 | 0.82 | CHRNA7 (0.60) | CHRNA7KCNH2HTR3ACHRNB4CHRNA3 | |
| SCHEMBL928094 | 0.81 | CHRNA7 (0.58) | CHRNA7MAPTTP53POLBKCNH2 | |
| SCHEMBL929606 | 0.80 | CHRNA7 (0.63) | CHRNA7MAPTTP53POLBHTR3A | |
| SCHEMBL928321 | 0.79 | CHRNA7 (0.62) | CHRNA7MAPTTP53KCNH2HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316836-A1 | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors | Abbott Laboratories (US) | 2011-05-04 | — | — | EP | disclosed |