Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31520503 | 0.84 | CASP3 (0.50) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL9449865 | 0.84 | CASP3 (0.50) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL29398691 | 0.84 | CASP3 (0.50) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL25186508 | 0.82 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL119197 | 0.82 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL29400907 | 0.82 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL30759963 | 0.82 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL14265318 | 0.82 | CASP3 (0.59) | CASP3KMT2AEPHX2MDM4TP53 | |
| SCHEMBL17130775 | 0.82 | PTPN1 (0.50) | CASP3PTPN1 | |
| SCHEMBL11902467 | 0.82 | CASP3 (0.45) | CASP3KMT2AMDM4TP53PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170232055-A1 | METHODS OF SYNTHESIZING GAMMA-AAPEPTIDES, GAMMA-AAPEPTIDE BUILDING BLOCKS, GAMMA-AAPEPTIDE LIBRARIES, AND GAMMA-AAPEPTIDE INHIBITORS OF ALPHA-BETA40 AGGREGATES | UNIVERSITY OF SOUTH FLORIDA (US) | 2017-08-17 | — | — | US | disclosed |
| US-20160209422-A1 | METHODS OF SYNTHESIZING y-AAPEPTIDES, y-AAPEPTIDE BUILDING BLOCKS, y-AAPEPTIDE LIBRARIES, AND y-AAPEPTIDE INHIBITORS OF Ab40 AGGREGATES | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170232055-A1 | METHODS OF SYNTHESIZING GAMMA-AAPEPTIDES, GAMMA-AAPEPTIDE BUILDING BLOCKS, GAMMA-AAPEPTIDE LIBRARIES, AND GAMMA-AAPEPTIDE INHIBITORS OF ALPHA-BETA40 AGGREGATES | APP, APBA1, IAPP | CASP3 1860/4885KMT2A 2836/4885PIN1 1386/4885 |
| US-20160209422-A1 | METHODS OF SYNTHESIZING y-AAPEPTIDES, y-AAPEPTIDE BUILDING BLOCKS, y-AAPEPTIDE LIBRARIES, AND y-AAPEPTIDE INHIBITORS OF Ab40 AGGREGATES | APBA1, APP, IAPP | CASP3 1810/4885KMT2A 2287/4885PIN1 2075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.