Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TET3 | O43151 | 1/20 | 0.58 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.58 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.58 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.58 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.58 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503762 | 0.96 | AKR1C1 (0.68) | AKR1C1HDAC4HSD11B1KMT2ATET3 | |
| Hydrochloric Acid SCHEMBL5741878 | 0.94 | AKR1C1 (0.66) | AKR1C1HDAC4HSD11B1KMT2ATET3 | |
| SCHEMBL694700 | 0.94 | AKR1C1 (0.66) | AKR1C1HDAC4HSD11B1KMT2ATET3 | |
| SCHEMBL75310 | 0.92 | TET3 (0.61) | AKR1C1HDAC4HSD11B1KMT2ATET3 | |
| SCHEMBL3443425 | 0.84 | HDAC4 (0.61) | AKR1C1HDAC4HSD11B1KMT2ATET3 | |
| SCHEMBL27299189 | 0.84 | HSD11B1 (0.49) | AKR1C1HDAC4HSD11B1KMT2ATET3 | |
| SCHEMBL11075416 | 0.83 | KMT2A (0.54) | AKR1C1HDAC4HSD11B1KMT2ATET3 | |
| SCHEMBL4005636 | 0.83 | DRD2 (0.58) | AKR1C1HDAC4HSD11B1KMT2ATET3 | |
| SCHEMBL1625869 | 0.83 | MAP4K4 (0.61) | AKR1C1HDAC4HSD11B1KMT2ATET3 | |
| SCHEMBL1952 | 0.82 | HDAC4 (0.59) | HDAC4HSD11B1ALDH1A1FFAR2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 300 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| EP-3573972-B1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2026-01-14 | — | — | EP | disclosed |
| EP-4377295-B1 | HALOACETHYDRAZIDES USEFUL AS AEP INHIBITORS | HOFFMANN LA ROCHE (CH) | 2025-06-11 | — | — | EP | disclosed |
| US-20240217928-A1 | HALOACETHYDRAZIDES USEFUL AS AEP INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2024-07-04 | — | — | US | disclosed |
| EP-4377295-A1 | HALOACETHYDRAZIDES USEFUL AS AEP INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2024-06-05 | — | — | EP | disclosed |
| CN-117813284-A | Halogenated acethydrazide as AEP inhibitor | 豪夫迈·罗氏有限公司 | 2024-04-02 | — | — | CN | disclosed |
| EP-3002280-B1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIV GREENWICH (GB) | 2023-05-24 | — | — | EP | disclosed |
| WO-2023006645-A1 | HALOACETHYDRAZIDES USEFUL AS AEP INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-02-02 | — | — | WO | disclosed |
| US-20220363662-A1 | COMPOUNDS AS LXR AGONISTS | Integral Biosciences Privated Limited (IN) | 2022-11-17 | — | — | US | disclosed |
| WO-2022224166-A1 | COMPOUNDS AS LXR AGONISTS | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2022-10-27 | — | — | WO | disclosed |
| US-4355042-A | A CYCLOBUTANE CARBOXYLIC ACID DERIVATIVE | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) | 1982-10-19 | — | — | US | disclosed |
| US-4348409-A | MITICIDES, NEMATOCIDES | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) | 1982-09-07 | — | — | US | disclosed |
| US-4339458-A | HALOCYCLOBUTANECARBOXYLATES | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) | 1982-07-13 | — | — | US | disclosed |
| EP-0002620-B1 | CYCLOALKYL CARBOXYLIC ESTERS, INSECTICIDAL COMPOSITIONS CONTAINING THEM, AND METHODS FOR THEIR PREPARATION | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1981-11-25 | — | — | EP | disclosed |
| EP-0001566-B1 | CYCLOBUTANECARBOXYLIC ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS INSECTICIDES | BAYER AG (DE) | 1980-11-26 | — | — | EP | disclosed |
| US-4235926-A | DERIVATIVES OF CYCLOBUTANE | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) | 1980-11-25 | — | — | US | disclosed |
| EP-0002620-A1 | Cycloalkyl carboxylic esters, insecticidal compositions containing them, and methods for their preparation | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1979-06-27 | — | — | EP | disclosed |
| EP-0001566-A2 | Cyclobutanecarboxylic acid derivatives, processes for their preparation and their use as insecticides | BAYER AG (DE) | 1979-05-02 | — | — | EP | disclosed |
| US-4130656-A | INSECTICIDE, MITICIDE | CIBA-GEIGY CORPORATION (US) | 1978-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240217928-A1 | HALOACETHYDRAZIDES USEFUL AS AEP INHIBITORS | NHERF1, ENPP1, ATP6AP1 | AKR1C1 286/4885HDAC4 1447/4885HSD11B1 2880/4885 |
| US-20220363662-A1 | COMPOUNDS AS LXR AGONISTS | NR1H2, NR1H3, NR1H4 | AKR1C1 277/4885HDAC4 1227/4885HSD11B1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.