Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NQO1 | P15559 | 2/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25C | P30307 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17942574 | 0.86 | GABRP (0.43) | ALDH1A1KDM4EMEN1MAPTHPGD | |
| SCHEMBL23105530 | 0.81 | ALDH1A1 (0.61) | ALDH1A1KDM4EMEN1MAPTHPGD | |
| SCHEMBL24725891 | 0.79 | MAPT (0.41) | MAOBALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL24726918 | 0.79 | PARP1 (0.45) | MAOBMEN1HPGDKMT2ANQO1 | |
| SCHEMBL21638102 | 0.79 | TTR (0.47) | MAOBMEN1KMT2ANQO1CDC25A | |
| SCHEMBL23105436 | 0.79 | ALDH1A1 (0.41) | MAOBALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL31248014 | 0.79 | MAOB (0.41) | MAOBALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL2337790 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KDM4EMEN1MAPTHPGD | |
| SCHEMBL22450150 | 0.76 | KDM4E (0.42) | ALDH1A1KDM4EMEN1MAPTHPGD | |
| Iodide SCHEMBL8114884 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4EMEN1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3247692-B1 | INHIBITORS OF TRKA KINASE | GVK BIOSCIENCES PRIVATE LTD (IN) | 2022-09-07 | — | — | EP | disclosed |
| US-10336723-B2 | Inhibitors of TrkA kinase | GVK BIOSCIENCES PRIVATE LIMITED (IN) | 2019-07-02 | — | — | US | disclosed |
| US-20180009781-A1 | INHIBITORS OF TRKA KINASE | GVK BIOSCIENCES PRIVATE LIMITED (IN) | 2018-01-11 | — | — | US | disclosed |
| EP-3247692-A1 | INHIBITORS OF TRKA KINASE | GVK Biosciences Private Limited (IN) | 2017-11-29 | — | — | EP | disclosed |
| WO-2016116900-A1 | INHIBITORS OF TRKA KINASE | GVK BIOSCIENCES PRIVATE LIMITED (IN) | 2016-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009781-A1 | INHIBITORS OF TRKA KINASE | NGFR, NGF, NTRK1 | MAOB 2030/4885ALDH1A1 2186/4885KDM4E 2967/4885 |
| US-10336723-B2 | Inhibitors of TrkA kinase | NGFR, EDNRA, NGF | MAOB 1481/4885ALDH1A1 2317/4885KDM4E 3043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.