Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSL1 | P33121 | 4/20 | 0.55 |
| ▸ | ACSL6 | Q9UKU0 | 3/20 | 0.55 |
| ▸ | ACSL3 | O95573 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1796405 | 1.00 | ACSL1 (0.55) | ACSL1ACSL6ACSL3NPC1POLB | |
| SCHEMBL1794239 | 0.91 | ACSL1 (0.56) | ACSL1ACSL6ACSL3NPC1POLB | |
| SCHEMBL1794127 | 0.91 | ACSL1 (0.56) | ACSL1ACSL6ACSL3NPC1POLB | |
| SCHEMBL1794125 | 0.91 | ACSL1 (0.56) | ACSL1ACSL6ACSL3NPC1POLB | |
| SCHEMBL905368 | 0.82 | LSS (0.44) | ACSL1ACSL6ACSL3NPC1CHRNA7 | |
| Fumaric Acid SCHEMBL905389 | 0.82 | ACSL1 (0.46) | ACSL1ACSL6ACSL3CHRNA7 | |
| SCHEMBL8714467 | 0.73 | CHRNA7 (0.48) | MAOAMAOBHRH3CHRNA7KCNH2 | |
| Trifluoroacetic Acid SCHEMBL1792985 | 0.73 | CHRNA7 (0.81) | ACSL1ACSL6ACSL3NPC1POLB | |
| Trifluoroacetic Acid SCHEMBL1796865 | 0.73 | CHRNA7 (0.61) | ACSL1ACSL6ACSL3NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8718227 | 0.72 | CHRNA7 (0.47) | MAOAMAOBHRH3CHRNA7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951791-B2 | e.g. 2,7-bis-[(3R)-1-azabicyclo[2.2.2]octan-3-yloxy]-fluoren-9-one; alpha 7 Nicotinic acetylcholine receptors ligands; cognitive disorder, neurodegeneration, and neurodevelopmental disorders | ABBOTT LABORATORIES (US) | 2011-05-31 | — | — | US | disclosed |
| EP-2258682-A2 | Amino-substituted tricyclic derivatives and methods of use | Abbott Laboratories (US) | 2010-12-08 | — | — | EP | disclosed |
| US-20080161281-A1 | Amino-Substituted Tricyclic Derivatives and Methods of Use | ABBOTT LABORATORIES (US) | 2008-07-03 | — | — | US | disclosed |
| US-7365193-B2 | Amino-substituted tricyclic derivatives and methods of use | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-20050234031-A1 | Amino-substituted tricyclic derivatives and methods of use | ABBVIE INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050171079-A1 | Amino-substituted tricyclic derivatives and methods of use | SCHRIMPF MICHAEL R (US) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234031-A1 | Amino-substituted tricyclic derivatives and methods of use | CHRNA1, CHRM1, GALR1 | ACSL1 3873/4885ACSL6 4006/4885ACSL3 4036/4885 |
| US-20080161281-A1 | Amino-Substituted Tricyclic Derivatives and Methods of Use | CHRNA1, CHRM1, CHRNB1 | ACSL1 3594/4885ACSL6 3814/4885ACSL3 3958/4885 |
| US-20050171079-A1 | Amino-substituted tricyclic derivatives and methods of use | CHRM1, CHRM3, CHRNA1 | ACSL1 3492/4885ACSL6 3637/4885ACSL3 3994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.