Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ACSL3 | O95573 | 1/20 | 0.43 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.43 |
| ▸ | ACSL6 | Q9UKU0 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794125 | 0.90 | ACSL1 (0.56) | NPC1ACSL3ACSL1ACSL6CHRNA7 | |
| SCHEMBL1794239 | 0.90 | ACSL1 (0.56) | NPC1ACSL3ACSL1ACSL6CHRNA7 | |
| SCHEMBL1794127 | 0.90 | ACSL1 (0.56) | NPC1ACSL3ACSL1ACSL6CHRNA7 | |
| Fumaric Acid SCHEMBL905389 | 0.90 | ACSL1 (0.46) | LSSMAPTACSL3ACSL1ACSL6 | |
| Trifluoroacetic Acid SCHEMBL1796405 | 0.82 | ACSL1 (0.55) | NPC1ACSL3ACSL1ACSL6CHRNA7 | |
| Trifluoroacetic Acid SCHEMBL1794473 | 0.82 | ACSL1 (0.55) | NPC1ACSL3ACSL1ACSL6CHRNA7 | |
| SCHEMBL7328816 | 0.79 | LMNA (0.48) | NPC1MAPTACSL1ACSL6CHRM2 | |
| Hydrochloric Acid SCHEMBL7320442 | 0.78 | LMNA (0.47) | NPC1MAPTACSL1ACSL6CHRM2 | |
| SCHEMBL4198059 | 0.77 | LSS (0.50) | LSSCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL7324169 | 0.77 | LMNA (0.46) | NPC1MAPTACSL1ACSL6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656375-B1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | NEUROSEARCH AS (DK) | 2011-01-19 | — | — | EP | claimed |
| US-7750022-B2 | Quinuclidine derivatives and their pharmaceutical use | NEUROSEARCH A/S (DK) | 2010-07-06 | — | — | US | claimed |
| US-20060217415-A1 | Novel quinuclidine derivatives and their pharmaceutical use | ABBOTT LABORATORIES PATENT AND TRADEMARK DEPARTMENT (US) | 2006-09-28 | — | — | US | claimed |
| EP-1656375-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | NEUROSEARCH A/S (DK) | 2006-05-17 | — | — | EP | claimed |
| EP-1532144-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 2005-05-25 | — | — | EP | claimed |
| WO-2005016923-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | NEUROSEARCH A/S (DK) | 2005-02-24 | — | — | WO | claimed |
| WO-2004016608-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 2004-02-26 | — | — | WO | claimed |
| EP-1656375-B1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | NEUROSEARCH AS (DK) | 2011-01-19 | — | — | EP | disclosed |
| US-7750022-B2 | Quinuclidine derivatives and their pharmaceutical use | NEUROSEARCH A/S (DK) | 2010-07-06 | — | — | US | disclosed |
| US-20090005390-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S | 2009-01-01 | — | — | US | disclosed |
| EP-1905771-A2 | Quinuclidine derivatives and their use | NeuroSearch A/S (DK) | 2008-04-02 | — | — | EP | disclosed |
| US-20060217415-A1 | Novel quinuclidine derivatives and their pharmaceutical use | ABBOTT LABORATORIES PATENT AND TRADEMARK DEPARTMENT (US) | 2006-09-28 | — | — | US | disclosed |
| EP-1656375-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | NEUROSEARCH A/S (DK) | 2006-05-17 | — | — | EP | disclosed |
| US-20050245567-A1 | Novel quinuclidine derivatives and their use | NEUROSEARCH A/S (DK) | 2005-11-03 | — | — | US | disclosed |
| EP-1532144-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2005016923-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | NEUROSEARCH A/S (DK) | 2005-02-24 | — | — | WO | disclosed |
| WO-2004016608-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005390-A1 | NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE | ACHE, CHRNA5, CHRNA3 | LSS 3273/4885NPC1 2856/4885MAPT 467/4885 |
| US-20050245567-A1 | Novel quinuclidine derivatives and their use | ACHE, CHRNA5, CHRNA3 | LSS 3273/4885NPC1 2856/4885MAPT 467/4885 |
| US-20060217415-A1 | Novel quinuclidine derivatives and their pharmaceutical use | CHRNA5, ACHE, CHRNA3 | LSS 3117/4885NPC1 2739/4885MAPT 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.