[Leu5]Enkephalin

[Leu5]Enkephalin

SCHEMBL17951964

CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ OPRD1 P41143 14/20 0.67
▸ OPRM1 P35372 8/20 0.67
▸ OPRK1 P41145 3/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
[Leu5]Enkephalin SCHEMBL29687098 1.00 OPRD1 (0.67) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL631958 0.93 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL11399380 0.93 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL631959 0.93 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL30857 0.93 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL16189980 0.93 OPRD1 (0.75) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL25236888 0.93 OPRD1 (0.73) OPRD1OPRM1OPRK1
Enkephalin SCHEMBL30400052 0.93 OPRD1 (0.73) OPRD1OPRM1OPRK1
SCHEMBL14241976 0.92 OPRD1 (0.65) OPRD1OPRM1OPRK1
SCHEMBL12962865 0.92 OPRD1 (0.65) OPRD1OPRM1OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240189383-A1 Application of Inhibitors Targeting CD226 Molecules in Anti-Tumor Metastasis AIR FORCE MEDICAL UNIVERSITY (CN) 2024-06-13 — — US claimed
US-20240052418-A1 METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-02-15 — — US claimed
US-11814681-B2 Method for predicting a subjects response to SLC modulator therapy THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-11-14 — — US claimed
WO-2023179802-A1 APPLICATION OF INHIBITOR TARGETING CD226 MOLECULE IN ANTI-TUMOR METASTASIS 中国人民解放军空军军医大学 2023-09-28 — — WO claimed
EP-3773730-B1 DRUG DELIVERY FORMULATIONS UNIV CALIFORNIA (US) 2026-05-13 — — EP disclosed
EP-4731637-A1 METHODS OF CHEMICAL SYNTHESIS OF PEPTIDES Imperial College Innovations Limited (GB) 2026-04-29 — — EP disclosed
US-12564579-B2 Topical formulations of (1S)-1-phenyl-2-pyridin-2-ylethanamine BIOHAVEN THERAPEUTICS LTD. (VG) 2026-03-03 — — US disclosed
US-20250312463-A1 AUGMENTED PEPTIDE COMPOSITIONS AND METHODS Neo7Bioscience, Inc. (US) 2025-10-09 — — US disclosed
US-20250195441-A1 GASTRORETENTIVE FORMULATIONS CONTAINING PROTEIN OR PEPTIDE APET Holding B.V. (NL) 2025-06-19 — — US disclosed
US-20250115940-A1 CELL CULTURE PROCESS JANSSEN BIOTECH, INC. 2025-04-10 — — US disclosed
EP-4486301-A1 GASTRORETENTIVE FORMULATIONS CONTAINING PROTEIN OR PEPTIDE APeT Holding B.V. (NL) 2025-01-08 — — EP disclosed
CN-114126615-B Opioid receptor antagonist prodrugs 尼萨姆实验室公司 2024-12-31 — — CN disclosed
US-20230190719-A1 TOPICAL FORMULATIONS OF (1S)-1-PHENYL-2-PYRIDIN-2-YLETHANAMINE BIOHAVEN THERAPEUTICS LTD (US) 2023-06-22 — — US disclosed
EP-4168116-A1 TOPICAL FORMULATIONS OF (1S)-1-PHENYL-2-PYRIDIN-2-YLETHANAMINE Biohaven Therapeutics Ltd. (US) 2023-04-26 — — EP disclosed
WO-2023279211-A1 METAL-CONTAINING POLYMERS FOR MASS CYTOMETRY THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2023-01-12 — — WO disclosed
US-20220249365-A1 BIOERODIBLE IMPLANT FOR LONG-TERM DRUG DELIVERY AND ASSOCIATED METHODS OF MANUFACTURE AND USE Gesea Biosciences Inc. (US) 2022-08-11 — — US disclosed
EP-2695618-B2 Pharmaceutical composition comprising lacosamide and levetiracetam for use in the treatment of epilepsy UCB PHARMA GMBH (DE) 2022-05-11 — — EP disclosed
EP-3965765-A1 OPIOID RECEPTOR ANTAGONIST PRODRUGS Nirsum Laboratories, Inc. (US) 2022-03-16 — — EP disclosed
US-10297435-B2 Micro-nozzle array QUEEN'S UNIVERSITY AT KINGSTON (CA) 2019-05-21 — — US disclosed
US-20160217994-A1 Micro-Nozzle Array QUEEN'S UNIVERSITY AT KINGSTON (CA) 2016-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12564579-B2 Topical formulations of (1S)-1-phenyl-2-pyridin-2-ylethanamine CERS2, CNR2, FAAH2 OPRD1 696/4885OPRM1 507/4885OPRK1 1115/4885
US-20230190719-A1 TOPICAL FORMULATIONS OF (1S)-1-PHENYL-2-PYRIDIN-2-YLETHANAMINE TRPV1, PNN, SLC18A2 OPRD1 51/4885OPRM1 99/4885OPRK1 49/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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