Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 18/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 17/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10613747 | 0.83 | TRPV4 (0.55) | TRPV4CYP11B2CYP11B1 | |
| SCHEMBL10613739 | 0.83 | TRPV4 (0.55) | TRPV4CYP11B2CYP11B1 | |
| SCHEMBL28606434 | 0.82 | TRPV4 (0.53) | TRPV4CYP11B2CYP11B1 | |
| SCHEMBL17227569 | 0.81 | FDPS (0.40) | TRPV4 | |
| SCHEMBL16953314 | 0.80 | TRPV4 (0.52) | TRPV4CYP11B2CYP11B1 | |
| SCHEMBL923510 | 0.80 | TRPV4 (0.52) | TRPV4CYP11B2CYP11B1 | |
| SCHEMBL286663 | 0.80 | TRPV4 (0.52) | TRPV4CYP11B2CYP11B1 | |
| SCHEMBL29630883 | 0.80 | TRPV4 (0.52) | TRPV4CYP11B2CYP11B1 | |
| SCHEMBL17954417 | 0.76 | TRPV4 (0.52) | TRPV4CYP11B2CYP11B1 | |
| SCHEMBL15471964 | 0.76 | TRPV4 (0.47) | TRPV4CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515888-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2021-03-31 | — | — | EP | disclosed |
| WO-2016118666-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2016-07-28 | — | — | WO | disclosed |