Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 2/20 | 0.50 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796391 | 0.92 | SMARCA2 (0.48) | SORT1SMARCA2SMARCA4MEN1KMT2A | |
| SCHEMBL1794785 | 0.91 | NPC1 (0.50) | SORT1SMARCA2SMARCA4KMOGRM5 | |
| SCHEMBL1793750 | 0.87 | SORT1 (0.53) | SORT1SMARCA2SMARCA4MEN1KMT2A | |
| SCHEMBL1795819 | 0.86 | GRM5 (0.56) | SORT1SMARCA2SMARCA4GRM5HDAC4 | |
| SCHEMBL1795233 | 0.85 | GRM5 (0.56) | SORT1SMARCA2SMARCA4MEN1KMT2A | |
| SCHEMBL1797439 | 0.84 | SMARCA2 (0.49) | SORT1SMARCA2SMARCA4KMOGRM5 | |
| SCHEMBL1797503 | 0.84 | SMARCA2 (0.60) | SORT1SMARCA2SMARCA4MEN1KMT2A | |
| SCHEMBL1796453 | 0.82 | SMARCA2 (0.61) | SORT1SMARCA2SMARCA4GRM5HDAC4 | |
| SCHEMBL1795182 | 0.82 | GRM5 (0.50) | SORT1SMARCA2SMARCA4MEN1KMT2A | |
| SCHEMBL7913044 | 0.81 | SORT1 (0.58) | SORT1SMARCA2SMARCA4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |