Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794085 | 0.84 | GRM5 (0.54) | GRM5SORT1SMARCA2SMARCA4MEN1 | |
| SCHEMBL1795467 | 0.82 | SORT1 (0.50) | GRM5SORT1SMN1; SMN2SMARCA2SMARCA4 | |
| SCHEMBL1797572 | 0.80 | GRM5 (0.51) | GRM5SORT1SMARCA2SMARCA4MEN1 | |
| SCHEMBL1797599 | 0.79 | ABL1 (0.53) | GRM5SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL1794680 | 0.79 | GRM5 (0.55) | GRM5SORT1SMN1; SMN2SMARCA2SMARCA4 | |
| SCHEMBL1798486 | 0.78 | SMN1; SMN2 (0.47) | GRM5SMN1; SMN2MEN1KMT2AKMO | |
| SCHEMBL1797438 | 0.78 | GRM5 (0.57) | GRM5ATR | |
| SCHEMBL4769554 | 0.78 | KMO (0.50) | SMN1; SMN2KMOMAPTNPC1RAB9A | |
| SCHEMBL1794247 | 0.75 | SORT1 (0.54) | GRM5SORT1SMARCA2SMARCA4MEN1 | |
| SCHEMBL1796391 | 0.74 | SMARCA2 (0.48) | GRM5SORT1SMN1; SMN2SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |