SCHEMBL17956473

SCHEMBL17956473

CC(C)(C)OC(=O)N1C[C@H](NOCc2ccccc2)CC[C@@]1(C(=O)O)c1c(Cl)cc(Cl)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 2/20 0.38
KMT2A Q03164 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
YAP1 P46937 2/20 0.34
STS P08842 3/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPK8 P45983 1/20 0.33
GRM5 P41594 1/20 0.33
CCNT1 O60563 1/20 0.33
BRD4 O60885 1/20 0.33
BCHE P06276 1/20 0.33
HTR6 P50406 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17956491 0.88 KMT2A (0.36) USP30KMT2AL3MBTL1NPC1RAB9A
SCHEMBL17956366 0.87 USP30 (0.38) USP30KMT2AL3MBTL1YAP1STS
SCHEMBL17956418 0.82 GPR119 (0.36) USP30KMT2AL3MBTL1YAP1STS
SCHEMBL17956404 0.81 GPR119 (0.36) USP30KMT2AL3MBTL1YAP1STS
SCHEMBL17956445 0.81 HDAC1 (0.39) USP30KMT2ANPC1RAB9AYAP1
SCHEMBL17956406 0.81 KMT2A (0.37) USP30KMT2AL3MBTL1YAP1STS
SCHEMBL17956439 0.80 GPR119 (0.38) USP30L3MBTL1YAP1STS
SCHEMBL17956511 0.80 GPR119 (0.40) STS
SCHEMBL17956448 0.80 HTR5A (0.34) USP30KMT2AALDH1A1
SCHEMBL17956374 0.80 STS (0.37) USP30RAB9ASTS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10000491-B2 Process for producing diazabicyclooctane derivative and intermediate thereof MEIJI SEIKA PHARMA CO., LTD. (JP) 2018-06-19 US disclosed
US-10000492-B2 Process for producing diazabicyclooctane derivative MEIJI SEIKA PHARMA CO., LTD. (JP) 2018-06-19 US disclosed
US-20170283415-A1 PROCESS FOR PRODUCING DIAZABICYCLOOCTANE DERIVATIVE MEIJI SEIKA PHARMA CO., LTD. (JP) 2017-10-05 US disclosed
US-20160264573-A1 PROCESS FOR PRODUCING DIAZABICYCLOOCTANE DERIVATIVE AND INTERMEDIATE THEREOF MEIJI SEIKA PHARMA CO., LTD. (JP) 2016-09-15 US disclosed
EP-3050883-A1 PRODUCTION METHOD FOR DIAZABICYCLOOCTANE DERIVATIVE AND INTERMEDIARY BODY THEREOF Meiji Seika Pharma Co., Ltd. (JP) 2016-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10000492-B2 Process for producing diazabicyclooctane derivative OGFOD1, HAAO, CLCN2 USP30 2537/4885KMT2A 2276/4885L3MBTL1 3014/4885
US-20170283415-A1 PROCESS FOR PRODUCING DIAZABICYCLOOCTANE DERIVATIVE OGFOD1, HAAO, CLCN2 USP30 2537/4885KMT2A 2276/4885L3MBTL1 3014/4885
US-20160264573-A1 PROCESS FOR PRODUCING DIAZABICYCLOOCTANE DERIVATIVE AND INTERMEDIATE THEREOF CLCN2, ODC1, KCNN4 USP30 3438/4885KMT2A 1933/4885L3MBTL1 2419/4885
US-10000491-B2 Process for producing diazabicyclooctane derivative and intermediate thereof CLCN2, ODC1, KCNN4 USP30 3438/4885KMT2A 1933/4885L3MBTL1 2419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.