SCHEMBL17959

SCHEMBL17959

FC(F)(F)c1ccnc(Cl)n1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.50
GABRG2 P18507 1/20 0.50
GABRB3 P28472 1/20 0.50
GABRA3 P34903 1/20 0.50
ADRB1 P08588 1/20 0.43
GAA P10253 2/20 0.39
MAPT P10636 1/20 0.39
LOXL2 Q9Y4K0 2/20 0.38
SYK P43405 5/20 0.38
TAS2R14 Q9NYV8 1/20 0.37
LOX P28300 1/20 0.37
SMARCA2 P51531 1/20 0.37
SMARCA4 P51532 1/20 0.37
IDH1 O75874 2/20 0.36
HTR2C P28335 3/20 0.36
HTR2A P28223 2/20 0.36
HTR2B P41595 2/20 0.36
PKM P14618 1/20 0.36
IDH2 P48735 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31038939 1.00 GABRA1 (0.50) GABRA1GABRG2GABRB3GABRA3ADRB1
Formamide SCHEMBL6983800 0.89 GABRA1 (0.43) GABRA1GABRG2GABRB3GABRA3ADRB1
SCHEMBL31543495 0.84 GABRA1 (0.39) GABRA1GABRG2GABRB3GABRA3ADRB1
SCHEMBL1661164 0.84 GABRA1 (0.39) GABRA1GABRG2GABRB3GABRA3ADRB1
SCHEMBL30632766 0.83 GABRA1 (0.38) GABRA1GABRG2GABRB3GABRA3ADRB1
SCHEMBL26686630 0.83 GABRA1 (0.38) GABRA1GABRG2GABRB3GABRA3ADRB1
SCHEMBL2014949 0.83 GABRA1 (0.38) GABRA1GABRG2GABRB3GABRA3ADRB1
SCHEMBL16115627 0.79 GABRA1 (0.36) GABRA1GABRG2GABRB3GABRA3LOXL2
SCHEMBL7171955 0.79 CYP3A4 (0.46) GABRA1GABRG2GABRB3GABRA3GAA
SCHEMBL15094782 0.78 IDH1 (0.48) GABRA1GABRG2GABRB3GABRA3ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1250 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4688155-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS Bial-Portela & CA, S.A. (PT) 2026-02-11 EP claimed
WO-2025023852-A1 MORPHOLINE OREXIN RECEPTOR ANTAGONISTS BIAL - PORTELA & CA., S.A. (PT) 2025-01-30 WO claimed
CN-110821065-B Exterior wall coating construction method 深圳陆城装饰设计工程有限公司 2022-01-14 CN claimed
CN-110821065-A Exterior wall coating construction method 深圳陆城装饰设计工程有限公司 2020-02-21 CN claimed
CN-110003117-A A kind of ferulic amide derivative and its preparation and use containing trifluoromethyl pyrimidine 贵阳学院 2019-07-12 CN claimed
CN-106188013-A A kind of synthetic method of 6 trifluoromethyl N (2 trifluoro methyl indole 5 base) methyl 4 pyrimidinamine 中国药科大学 2016-12-07 CN claimed
CN-102887860-B Preparation method of 4-chloro-6-trifluoromethylpyrimidine type compound SHANGHAI TITAN TECHNOLOGY CO LTD 2015-07-01 CN claimed
CN-101792420-B Preparation of halogenated n-heteroaromatic polyhalogen derivatives SALTIGO GMBH (DE) 2014-10-08 CN claimed
CN-102887860-A Preparation method of 4-chloro-6-trifluoromethylpyrimidine type compound SHANGHAI TITAN TECHNOLOGY CO LTD 2013-01-23 CN claimed
CN-101792420-A Preparation of halogenated n-heteroaromatic polyhalogen derivatives SALTIGO GMBH 2010-08-04 CN claimed
WO-2026107349-A1 HETEROCYCLIC INHIBITORS OF CYCLIN-DEPENDENT KINASES ANTARES THERAPEUTICS, INC. (US) 2026-05-21 WO disclosed
CN-117659017-B TRPML1/2 modulator compound, pharmaceutical composition, preparation method and application thereof 北京华益健康药物研究中心 2026-05-15 CN disclosed
EP-4731623-A1 CARBOLINE COMPOUNDS AND USE THEREOF PTC Therapeutics, Inc. (US) 2026-04-29 EP disclosed
US-12595255-B2 Heteroaryl-substituted imidazole derivatives HOFFMANN-LA ROCHE INC. (US) 2026-04-07 US disclosed
US-20260083851-A1 POTENT ASGPR-BINDING HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS AVILAR THERAPEUTICS, INC. (US) 2026-03-26 US disclosed
EP-0937722-A1 Benzimidazole derivatives as cyclooxygenase-2 inhibitors PFIZER INC. (US) 1999-08-25 EP disclosed
CN-1214339-A Pyrazole derivatives, their preparation and their use in pharmaceuticals HOECHST MARION ROUSSEL DE GMBH (DE) 1999-04-21 CN disclosed
EP-0908456-A1 Pyrazole derivatives, their preparation and their use in drugs Hoechst Marion Roussel Deutschland GmbH (DE) 1999-04-14 EP disclosed
EP-0806422-A2 Anti-cataract agent Senju Pharmaceutical Co., Ltd. (JP) 1997-11-12 EP disclosed
EP-0163280-A1 Pyrimidylphosphoric acid esters, process for their preparation and their use for pest control BASF Aktiengesellschaft (DE) 1985-12-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260083851-A1 POTENT ASGPR-BINDING HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS ASGR1, FCGR2A, FCGR3B GABRA1 223/4885GABRG2 190/4885GABRB3 282/4885
US-12595255-B2 Heteroaryl-substituted imidazole derivatives CLIC1, CYP2B6, CYP2D6 GABRA1 483/4885GABRG2 1823/4885GABRB3 1259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.