Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31346130 | 0.79 | PGK1 (0.39) | APP | |
| SCHEMBL26607321 | 0.79 | PGK1 (0.39) | APP | |
| SCHEMBL19914418 | 0.77 | PDE2A (0.41) | EPHX2PDE2AAPPKCNH2TMEM97 | |
| SCHEMBL19411097 | 0.77 | PDE2A (0.37) | EPHX2PDE2A | |
| SCHEMBL19899632 | 0.73 | PDE2A (0.41) | EPHX2PDE2AAPPKCNH2TMEM97 | |
| SCHEMBL18894055 | 0.71 | CA9 (0.36) | — | |
| SCHEMBL21066389 | 0.70 | EPHX2 (0.39) | EPHX2PDE2A | |
| SCHEMBL319598 | 0.69 | KIF11 (0.41) | — | |
| SCHEMBL22206764 | 0.69 | EPHX2 (0.40) | EPHX2PDE2AKCNH2 | |
| SCHEMBL29453105 | 0.69 | EPHX2 (0.40) | EPHX2PDE2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3253755-B1 | NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES | PFIZER (US) | 2020-08-26 | — | — | EP | disclosed |
| EP-3253755-B1 | NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES | PFIZER (US) | 2020-08-26 | — | — | EP | disclosed |
| CN-107406445-B | Cyclopropylbenzofuranyl pyridopyrazine diones | 辉瑞公司 | 2019-12-24 | — | — | CN | disclosed |
| US-9765073-B2 | Cyclopropabenzofuranyl pyridopyrazinediones | PFIZER INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9765073-B2 | Cyclopropabenzofuranyl pyridopyrazinediones | PFIZER INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9765073-B2 | Cyclopropabenzofuranyl pyridopyrazinediones | PFIZER INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170096428-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170096428-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170096428-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER INC. | 2017-04-06 | — | — | US | disclosed |
| WO-2016125048-A1 | NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES | PFIZER INC. (US) | 2016-08-11 | — | — | WO | disclosed |
| WO-2016125048-A1 | NOVEL CYCLOPROPABENZOFURANYL PYRIDOPYRAZINEDIONES | PFIZER INC. (US) | 2016-08-11 | — | — | WO | disclosed |
| US-20160222007-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160222007-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160222007-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | PFIZER (US) | 2016-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160222007-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | CYP4B1, RXRB, ADRA2B | EPHX2 2201/4885PDE2A 291/4885APP 3160/4885 |
| US-20170096428-A1 | Novel Cyclopropabenzofuranyl Pyridopyrazinediones | CYP4B1, RXRB, ADRA2B | EPHX2 2201/4885PDE2A 291/4885APP 3160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.