Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.42 |
| ▸ | MITF | O75030 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24485098 | 0.75 | ALDH1A1 (0.56) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL20660787 | 0.71 | F2 (0.46) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL15613247 | 0.70 | MEN1 (0.39) | ALDH1A1RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL25280921 | 0.68 | LMNA (0.48) | ALDH1A1RAB9ANPC1SMN1; SMN2TSHR | |
| SCHEMBL25228566 | 0.67 | ALDH1A1 (0.40) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL15768068 | 0.67 | POLB (0.42) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL24779602 | 0.66 | ALDH1A1 (0.64) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1431846 | 0.65 | POLB (0.56) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1431393 | 0.65 | POLB (0.56) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL13578041 | 0.65 | POLB (0.56) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016119707-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2016-08-04 | — | — | WO | disclosed |
| WO-2016119707-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2016-08-04 | — | — | WO | disclosed |