Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.64 |
| ▸ | HTT | P42858 | 11/20 | 0.64 |
| ▸ | NPC1 | O15118 | 9/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.64 |
| ▸ | MITF | O75030 | 7/20 | 0.64 |
| ▸ | RAB9A | P51151 | 12/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 7/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 5/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2895158 | 0.85 | ALDH1A1 (0.61) | ALDH1A1HTTNPC1SMN1; SMN2MITF | |
| SCHEMBL29451272 | 0.84 | KDM4E (0.49) | ALDH1A1HTTNPC1SMN1; SMN2MITF | |
| SCHEMBL29451589 | 0.84 | RAB9A (0.48) | ALDH1A1HTTNPC1SMN1; SMN2MITF | |
| SCHEMBL24779604 | 0.84 | ALDH1A1 (0.68) | ALDH1A1HTTNPC1SMN1; SMN2MITF | |
| SCHEMBL2888078 | 0.82 | HTT (0.69) | ALDH1A1HTTNPC1SMN1; SMN2MITF | |
| SCHEMBL29451337 | 0.81 | NPC1 (0.46) | ALDH1A1HTTNPC1SMN1; SMN2MITF | |
| SCHEMBL29451407 | 0.81 | RAB9A (0.46) | ALDH1A1HTTNPC1SMN1; SMN2MITF | |
| SCHEMBL29452248 | 0.81 | ALDH1A1 (0.64) | ALDH1A1HTTNPC1SMN1; SMN2MITF | |
| SCHEMBL29451604 | 0.79 | RAB9A (0.45) | ALDH1A1HTTNPC1SMN1; SMN2MITF | |
| SCHEMBL29451457 | 0.79 | RAB9A (0.45) | ALDH1A1HTTNPC1SMN1; SMN2MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4351518-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | Universitetet I Oslo (NO) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022258992-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | UNIVERSITETET I OSLO (NO) | 2022-12-15 | — | — | WO | disclosed |
| WO-2022258992-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | UNIVERSITETET I OSLO (NO) | 2022-12-15 | — | — | WO | disclosed |