Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | GLA | P06280 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11418276 | 0.87 | KMT2A (0.51) | KDM4EGAAGLAALDH1A1NPSR1 | |
| SCHEMBL5912674 | 0.78 | ERCC5 (0.57) | KDM4EGAAGLAALDH1A1NPSR1 | |
| SCHEMBL8628843 | 0.77 | UCHL1 (0.45) | KDM4EGAAGLAALDH1A1NPSR1 | |
| SCHEMBL25428155 | 0.75 | ALDH1A1 (0.52) | KDM4EGAAGLAALDH1A1NPSR1 | |
| SCHEMBL20413798 | 0.75 | KDM4E (0.56) | KDM4EGAAGLAALDH1A1NPSR1 | |
| SCHEMBL1257597 | 0.74 | ALDH1A1 (0.76) | GLAALDH1A1MAPK1HPGDKMT2A | |
| SCHEMBL8940857 | 0.74 | TSHR (0.59) | KDM4EGAAGLAALDH1A1NPSR1 | |
| SCHEMBL12556339 | 0.74 | KMT2A (0.50) | KDM4EGAAGLAALDH1A1NPSR1 | |
| SCHEMBL15998958 | 0.74 | TSHR (0.74) | KDM4EGAAGLAALDH1A1NPSR1 | |
| SCHEMBL31138462 | 0.73 | IDO1 (0.50) | KDM4EGAAGLAALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123392-A2 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-08-04 | — | — | WO | disclosed |