Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 3/20 | 0.38 |
| ▸ | CDK8 | P49336 | 3/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 2/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17963610 | 1.00 | CYP11B2 (0.48) | CYP11B2KMT2AHDAC4GABRA5CCNC | |
| SCHEMBL17987303 | 0.86 | CYP11B2 (0.60) | CYP11B2KMT2AHDAC4GABRA5CCNC | |
| SCHEMBL17963596 | 0.86 | CYP11B2 (0.60) | CYP11B2KMT2AHDAC4GABRA5CCNC | |
| SCHEMBL17963597 | 0.86 | CYP11B2 (0.60) | CYP11B2KMT2AHDAC4GABRA5CCNC | |
| SCHEMBL17987412 | 0.81 | CYP11B2 (0.54) | CYP11B2KMT2AHDAC4RAB9ANPC1 | |
| SCHEMBL20546679 | 0.81 | CYP11B2 (0.54) | CYP11B2KMT2AHDAC4RAB9ANPC1 | |
| SCHEMBL17987413 | 0.81 | CYP11B2 (0.54) | CYP11B2KMT2AHDAC4RAB9ANPC1 | |
| SCHEMBL17963580 | 0.80 | ALDH1A1 (0.41) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL17987316 | 0.78 | RAB9A (0.45) | CYP11B2KMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL20547069 | 0.76 | KMT2A (0.43) | CYP11B2KMT2AHDAC4GABRA5CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250569-B1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-01-09 | — | — | EP | disclosed |
| US-10131642-B1 | Aldosterone synthase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-11-20 | — | — | US | disclosed |
| US-20180312475-A1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-11-01 | — | — | US | disclosed |
| EP-3250569-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2017-12-06 | — | — | EP | disclosed |
| WO-2016123275-A1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-08-04 | — | — | WO | disclosed |
| WO-2016123275-A1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312475-A1 | ALDOSTERONE SYNTHASE INHIBITORS | CYP21A2, CYP11B1, CYP17A1 | CYP11B2 5/4885KMT2A 3968/4885HDAC4 2735/4885 |
| US-10131642-B1 | Aldosterone synthase inhibitors | CYP21A2, CYP11B1, CYP17A1 | CYP11B2 5/4885KMT2A 3968/4885HDAC4 2735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.