Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28709691 | 0.85 | HTT (0.48) | NOTUMHTTTRPV1GAACHRNB2 | |
| SCHEMBL13041718 | 0.80 | HTT (0.43) | F7F3SARM1SIRT2SIRT6 | |
| SCHEMBL1819931 | 0.80 | NOTUM (0.53) | NOTUMHTTTRPV1GAAPOLQ | |
| SCHEMBL1532229 | 0.78 | RXFP1 (0.48) | HTTTSHRCYP3A4CYP2C9 | |
| SCHEMBL1577273 | 0.77 | NOTUM (0.50) | F7F3SARM1SIRT2SIRT6 | |
| Hydrochloric Acid SCHEMBL17785084 | 0.76 | NOTUM (0.49) | F7F3SARM1SIRT2SIRT6 | |
| SCHEMBL1850567 | 0.75 | HTT (0.46) | NOTUMHTTTRPV1GAAHPGD | |
| SCHEMBL3230643 | 0.74 | CHRNB2 (0.53) | HTTTRPV1CHRNB2CHRNA4KCNN4 | |
| SCHEMBL6834283 | 0.74 | POLB (0.51) | NOTUMHTTTRPV1CHRNB2CHRNA4 | |
| SCHEMBL28786393 | 0.73 | RECQL (0.45) | F7F3SARM1SIRT2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016124553-A1 | 2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2016-08-11 | — | — | WO | claimed |