Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 7/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | KCNA1 | Q09470 | 3/20 | 0.41 |
| ▸ | KCNAB1 | Q14722 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16645110 | 0.84 | ESR2 (0.56) | NAMPTPTPN1NPC1RAB9A | |
| SCHEMBL16634913 | 0.81 | KCNA1 (0.49) | TMPRSS2NAMPTPTPN2PTPN1KCNA1 | |
| SCHEMBL16634693 | 0.81 | NAMPT (0.62) | TMPRSS2NAMPTPTPN2PTPN1KCNA1 | |
| SCHEMBL17969239 | 0.80 | NAMPT (0.44) | TMPRSS2NAMPTPTPN2PTPN1KCNA1 | |
| SCHEMBL16634766 | 0.80 | KDM4E (0.49) | TMPRSS2NAMPTPTPN2PTPN1KCNA1 | |
| SCHEMBL16634834 | 0.77 | NAMPT (0.75) | NAMPTPTPN2PTPN1MAPTHTT | |
| SCHEMBL17969245 | 0.77 | TMPRSS2 (0.40) | TMPRSS2NAMPTPTPN2PTPN1KCNA1 | |
| SCHEMBL17969238 | 0.77 | TMPRSS2 (0.44) | TMPRSS2NAMPTPTPN2PTPN1KCNA1 | |
| SCHEMBL16634896 | 0.77 | NAMPT (0.46) | TMPRSS2NAMPTPTPN2PTPN1KCNA1 | |
| SCHEMBL16645178 | 0.75 | NAMPT (0.63) | NAMPTMLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229835-A1 | NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS | ELI LILLY AND COMPANY | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229835-A1 | NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS | NAMPT, NAPRT, NNMT | TMPRSS2 1372/4885NAMPT 1/4885PTPN2 4436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.