Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17970371 | 0.84 | EZH2 (0.35) | EZH2MGLLP2RX3P2RX2 | |
| SCHEMBL2594898 | 0.84 | NR4A1 (0.38) | EZH2ALDH1A1MGLL | |
| SCHEMBL17970581 | 0.83 | EZH2 (0.35) | EZH2ALDH1A1MGLLP2RX3P2RX2 | |
| SCHEMBL2591110 | 0.81 | MAPT (0.40) | EZH2ALDH1A1HTT | |
| SCHEMBL26265512 | 0.78 | EZH2 (0.46) | EZH2MGLL | |
| SCHEMBL19621047 | 0.77 | LMNA (0.44) | EZH2ALDH1A1LMNA | |
| SCHEMBL17970374 | 0.74 | KDM4E (0.34) | ALDH1A1LMNAHTT | |
| SCHEMBL17970567 | 0.73 | ALDH1A1 (0.34) | ALDH1A1LMNAHTT | |
| SCHEMBL17970560 | 0.72 | KDM4E (0.32) | ALDH1A1LMNAHTT | |
| SCHEMBL18676860 | 0.72 | GABRA1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773754-B1 | Compounds for use in the treatment of T-cell mediated diseases | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2016-08-03 | — | — | EP | disclosed |