Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | POLB | P06746 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | HTT | P42858 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MITF | O75030 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17988268 | 0.85 | KMT2A (0.55) | NPC1RAB9AKMT2APOLBTDP1 | |
| SCHEMBL13236077 | 0.84 | KMT2A (0.54) | NPC1RAB9AATMKMT2APOLB | |
| SCHEMBL8370191 | 0.80 | KMT2A (0.61) | NPC1RAB9AATMKMT2APOLB | |
| SCHEMBL8370192 | 0.80 | KMT2A (0.61) | NPC1RAB9AATMKMT2APOLB | |
| SCHEMBL12039474 | 0.79 | RAB9A (0.50) | NPC1RAB9AKMT2APOLBTDP1 | |
| SCHEMBL11873955 | 0.79 | KMT2A (0.56) | NPC1RAB9AATMKMT2APOLB | |
| SCHEMBL11873948 | 0.79 | KMT2A (0.56) | NPC1RAB9AATMKMT2APOLB | |
| SCHEMBL11843258 | 0.79 | KMT2A (0.56) | NPC1RAB9AATMKMT2APOLB | |
| SCHEMBL15201189 | 0.79 | MAPT (0.57) | NPC1RAB9AATMKMT2APOLB | |
| SCHEMBL15201190 | 0.79 | MAPT (0.57) | NPC1RAB9AATMKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160374997-A1 | ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2016-12-29 | — | — | US | disclosed |
| US-20160220510-A1 | ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2016-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160374997-A1 | ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS | AARS1, EPRS1, EEF1G | NPC1 4142/4885RAB9A 1810/4885ATM 1896/4885 |
| US-20160220510-A1 | ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS | AARS1, EPRS1, EEF1G | NPC1 4142/4885RAB9A 1810/4885ATM 1896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.