Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | NQO2 | P16083 | 4/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | WDR5 | P61964 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1797990 | 1.00 | NPC1 (0.67) | NPC1RAB9ACASP3SENP8SENP7 | |
| Hydrochloric Acid SCHEMBL1798761 | 0.98 | NPC1 (0.65) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL1796438 | 0.94 | NPC1 (0.55) | NPC1RAB9ACASP3SENP8SENP7 | |
| Hydrochloric Acid SCHEMBL1795286 | 0.92 | TOP2A (0.56) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL1796738 | 0.90 | NPC1 (0.51) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL1798532 | 0.88 | HSD17B1 (0.55) | NPC1RAB9ACASP3SENP8SENP7 | |
| Hydrochloric Acid SCHEMBL1799501 | 0.88 | NPC1 (0.50) | NPC1RAB9ACASP3SENP8SENP7 | |
| Hydrochloric Acid SCHEMBL5788068 | 0.87 | HSD17B1 (0.54) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL8094911 | 0.85 | NPC1 (0.67) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL14519323 | 0.84 | HSD17B1 (0.50) | NPC1RAB9ACASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264487-A1 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | TIDWELL RICHARD R | 2006-11-23 | — | — | US | claimed |
| EP-1719767-A1 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | The University of North Carolina at Chapel Hill (US) | 2006-11-08 | — | — | EP | claimed |
| US-7951827-B2 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-05-31 | — | — | US | disclosed |
| US-20060264487-A1 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | TIDWELL RICHARD R | 2006-11-23 | — | — | US | disclosed |
| EP-1719767-A1 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | The University of North Carolina at Chapel Hill (US) | 2006-11-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264487-A1 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | PFAS, DHPS, DDO | NPC1 3545/4885RAB9A 1451/4885CASP3 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.