Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17978936 | 0.81 | TP53 (0.50) | L3MBTL1TP53HTT | |
| SCHEMBL17977057 | 0.80 | KMT2A (0.34) | ALOX5L3MBTL1KDM5ATP53TDP1 | |
| SCHEMBL19770245 | 0.78 | ALDH1A1 (0.44) | ALOX5L3MBTL1TSHRLMNA | |
| SCHEMBL27670262 | 0.74 | ACHE (0.32) | L3MBTL1KDM5ATP53SMN1; SMN2 | |
| SCHEMBL30684534 | 0.73 | CALCRL (0.33) | — | |
| SCHEMBL1814278 | 0.70 | CALCRL (0.37) | CHRM4 | |
| SCHEMBL17977094 | 0.68 | TGM2 (0.44) | L3MBTL1TSHR | |
| SCHEMBL16530402 | 0.67 | KMT2A (0.38) | L3MBTL1KDM5A | |
| SCHEMBL23297059 | 0.67 | KMT2A (0.33) | SMN1; SMN2 | |
| SCHEMBL23297056 | 0.67 | KMT2A (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3255993-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2017-12-20 | — | — | EP | disclosed |
| WO-2016130444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2016-08-18 | — | — | WO | disclosed |