Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.57 |
| ▸ | GRM5 | P41594 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795619 | 0.90 | SERPINE1 (0.69) | CYP2C9CYP2C19CYP1A2CYP3A4SERPINE1 | |
| SCHEMBL1797316 | 0.89 | SERPINE1 (0.68) | CYP2C9CYP2C19CYP1A2CYP3A4SERPINE1 | |
| SCHEMBL1797310 | 0.88 | SERPINE1 (0.57) | CYP2C9CYP2C19CYP1A2CYP3A4SERPINE1 | |
| SCHEMBL1798810 | 0.82 | SERPINE1 (0.84) | CYP3A4SERPINE1USP2 | |
| SCHEMBL1800112 | 0.81 | SERPINE1 (0.56) | CYP2C9CYP2C19CYP1A2CYP3A4SERPINE1 | |
| SCHEMBL1796607 | 0.81 | SERPINE1 (0.58) | CYP2C9CYP2C19CYP1A2CYP3A4SERPINE1 | |
| SCHEMBL1799657 | 0.81 | SERPINE1 (0.70) | CYP2C9CYP2C19CYP1A2CYP3A4SERPINE1 | |
| SCHEMBL1797516 | 0.79 | ALDH1A1 (0.50) | CYP2C9CYP2C19CYP1A2CYP3A4MAPT | |
| SCHEMBL1015370 | 0.78 | KDM4E (0.60) | CYP2C9CYP2C19CYP1A2CYP3A4SERPINE1 | |
| SCHEMBL1796028 | 0.77 | SERPINE1 (0.61) | CYP2C9CYP2C19CYP1A2CYP3A4SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951806-B2 | Plasminogen activator inhibitor-1 inhibitor | RENASCIENCE CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| US-20090124620-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | RENASCIENCE CO., LTD. (JP) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124620-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | SERPINE1, SERPINC1, SERPINB1 | CYP2C9 4023/4885CYP2C19 3450/4885CYP1A2 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.