Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20250818 | 1.00 | KCNH2 (0.52) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL20240428 | 1.00 | KCNH2 (0.52) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL17984858 | 0.93 | KCNH2 (0.49) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL19664875 | 0.93 | KCNH2 (0.49) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL17984839 | 0.92 | KCNH2 (0.62) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL19664899 | 0.92 | KCNH2 (0.62) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL20250851 | 0.92 | KCNH2 (0.62) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL17984080 | 0.92 | KCNH2 (0.51) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL17984909 | 0.91 | KCNH2 (0.52) | KCNH2CACNA1CSCN5APTGS1SLC6A2 | |
| SCHEMBL20240462 | 0.91 | KCNH2 (0.52) | KCNH2CACNA1CSCN5APTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227362-B2 | Anti-pulmonary tuberculosis nitroimidazole derivative | MEDSHINE DISCOVERY INC. (CN) | 2019-03-12 | — | — | US | disclosed |
| US-20180162878-A1 | ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE | MEDSHINE DISCOVERY INC. (CN) | 2018-06-14 | — | — | US | disclosed |
| US-20180162878-A1 | ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE | MEDSHINE DISCOVERY INC. (CN) | 2018-06-14 | — | — | US | disclosed |
| WO-2016119706-A1 | ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE | 南京明德新药研发股份有限公司 | 2016-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162878-A1 | ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE | NDUFV1, NDUFV2, MT-ND4 | KCNH2 3983/4885CACNA1C 4771/4885SCN5A 3769/4885 |
| US-10227362-B2 | Anti-pulmonary tuberculosis nitroimidazole derivative | NDUFV1, NDUFV2, MT-ND4 | KCNH2 3983/4885CACNA1C 4771/4885SCN5A 3769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.