Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | GRM6 | O15303 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12960157 | 0.84 | ALDH1A1 (0.55) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL8470075 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL4867920 | 0.83 | ALDH1A1 (0.65) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL21857518 | 0.81 | ALDH1A1 (0.62) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL20665497 | 0.81 | GRM6 (0.68) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL1983278 | 0.79 | ADORA1 (0.51) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL4473918 | 0.77 | MAPT (0.58) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL10710844 | 0.76 | GRM6 (1.00) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL8672363 | 0.76 | GRM6 (0.49) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL19086330 | 0.76 | GRM6 (0.49) | ALDH1A1MAPTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190016681-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-17 | — | — | US | disclosed |
| US-20190016681-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-17 | — | — | US | disclosed |
| EP-3400213-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | Rijksuniversiteit Groningen (NL) | 2018-11-14 | — | — | EP | disclosed |
| CN-108698995-A | Inhibitors of PD-1/PD-L1 protein/protein interactions | 格罗宁根大学 | 2018-10-23 | — | — | CN | disclosed |
| WO-2017118762-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2017-07-13 | — | — | WO | disclosed |
| WO-2017118762-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2017-07-13 | — | — | WO | disclosed |
| EP-3190103-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | Rijksuniversiteit Groningen (NL) | 2017-07-12 | — | — | EP | disclosed |
| EP-3190103-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | Rijksuniversiteit Groningen (NL) | 2017-07-12 | — | — | EP | disclosed |
| US-7951806-B2 | Plasminogen activator inhibitor-1 inhibitor | RENASCIENCE CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| US-20090124620-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | RENASCIENCE CO., LTD. (JP) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190016681-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | PDCD1, CD274, PDCD1LG2 | ALDH1A1 895/4885MAPT 3038/4885MEN1 3279/4885 |
| US-20090124620-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | SERPINE1, SERPINC1, SERPINB1 | ALDH1A1 800/4885MAPT 2975/4885MEN1 582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.