Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 14/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809553 | 0.86 | EZH2 (0.44) | RORCAAK1DRD2NAMPT | |
| SCHEMBL15765023 | 0.85 | MEN1 (0.38) | RORCAAK1DRD2NAMPT | |
| SCHEMBL15758544 | 0.83 | AQP1 (0.33) | — | |
| SCHEMBL15764934 | 0.82 | DRD2 (0.43) | RORCDRD2NAMPT | |
| SCHEMBL29116933 | 0.79 | RORC (0.38) | RORCDRD2NAMPT | |
| SCHEMBL29116906 | 0.78 | PARP1 (0.41) | RORCDRD2 | |
| SCHEMBL15765045 | 0.78 | EZH2 (0.40) | RORCDRD2 | |
| SCHEMBL17987807 | 0.77 | EZH2 (0.45) | RORCDRD2NAMPT | |
| SCHEMBL17974445 | 0.77 | DRD2 (0.42) | RORCDRD2NAMPT | |
| SCHEMBL29116905 | 0.75 | RORC (0.41) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160221994-A1 | Substituted 2,3-Dihydrobenzofuranyl Compounds And Uses Thereof | Karyopharm Therapeutics Inc. | 2016-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160221994-A1 | Substituted 2,3-Dihydrobenzofuranyl Compounds And Uses Thereof | BCL6, MALT1, BCL3 | RORC 281/4885AAK1 4030/4885DRD2 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.