Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | APEX1 | P27695 | 2/20 | 0.53 |
| ▸ | THPO | P40225 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | RGS12 | O14924 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | ERCC1 | P07992 | 7/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 7/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171986 | 0.81 | LMNA (0.53) | KDM4EHIF1AHSD17B10TDP1MAPT | |
| SCHEMBL29556990 | 0.79 | KDM4E (0.60) | KDM4EHIF1AHSD17B10TDP1MAPT | |
| SCHEMBL9674289 | 0.79 | KDM4E (0.60) | KDM4EHIF1AHSD17B10TDP1MAPT | |
| SCHEMBL10203658 | 0.77 | TRPV1 (0.47) | KDM4EHIF1AHSD17B10TDP1MAPT | |
| SCHEMBL9313486 | 0.77 | KDM4E (0.62) | KDM4EHIF1AHSD17B10TDP1MAPT | |
| SCHEMBL17993526 | 0.76 | KMT2A (0.64) | KDM4EMAPTLMNAHPGDPOLB | |
| SCHEMBL2734611 | 0.76 | KDM4E (0.67) | KDM4EHIF1AHSD17B10TDP1MAPT | |
| SCHEMBL13926590 | 0.76 | GAA (0.56) | KDM4ETDP1LMNAGAAEGFR | |
| SCHEMBL17993492 | 0.75 | EGFR (0.49) | HIF1AHSD17B10TDP1MAPTHPGD | |
| SCHEMBL3565748 | 0.75 | ALDH1A1 (0.57) | TDP1MAPTLMNAPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426108-B1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC (CA) | 2016-08-10 | — | — | EP | disclosed |