Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14423987 | 0.87 | POLB (0.43) | SMN1; SMN2BRD4BRD2SCN9ANTRK1 | |
| SCHEMBL14424466 | 0.84 | ATM (0.50) | SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL14424462 | 0.83 | EPHX1 (0.51) | ALDH1A1 | |
| SCHEMBL12199026 | 0.80 | BRD4 (0.41) | SMN1; SMN2ALDH1A1BRD4BRD2GAA | |
| SCHEMBL14266486 | 0.79 | LMNA (0.50) | ALDH1A1BRD4BRD2GAARIPK1 | |
| SCHEMBL3599701 | 0.77 | BRD4 (0.46) | ALDH1A1BRD4BRD2GAARIPK1 | |
| SCHEMBL19026668 | 0.76 | MLYCD (0.39) | SMN1; SMN2ALDH1A1GAANPC1RAB9A | |
| SCHEMBL27599899 | 0.76 | BRD4 (0.41) | ALDH1A1BRD4BRD2GAARIPK1 | |
| SCHEMBL10172966 | 0.76 | RIPK1 (0.40) | SMN1; SMN2ALDH1A1BRD4BRD2GAA | |
| SCHEMBL8260822 | 0.76 | RIPK1 (0.44) | ALDH1A1BRD4BRD2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183254-B1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC (CA) | 2017-06-21 | — | — | EP | disclosed |
| EP-2426108-B1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC (CA) | 2016-08-10 | — | — | EP | disclosed |