Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363240 | 0.82 | HDAC4 (0.59) | HDAC4ALDH1A1HSD11B1THRBHDAC1 | |
| SCHEMBL172001 | 0.80 | HDAC4 (0.50) | HDAC4ALDH1A1HSD11B1THRBHDAC1 | |
| SCHEMBL1100195 | 0.78 | HDAC4 (0.59) | HDAC4ALDH1A1HSD11B1THRBHDAC1 | |
| SCHEMBL14019859 | 0.78 | EPHX1 (0.56) | HDAC4ALDH1A1HSD11B1THRBHDAC1 | |
| SCHEMBL14817498 | 0.76 | SMN1; SMN2 (0.48) | HDAC4ALDH1A1HSD11B1THRBHDAC1 | |
| SCHEMBL169873 | 0.76 | ALDH1A1 (0.59) | HDAC4ALDH1A1HSD11B1THRBHTT | |
| SCHEMBL2722547 | 0.75 | AKR1C1 (0.57) | HDAC4HSD11B1THRBHDAC1HTT | |
| SCHEMBL5055163 | 0.75 | AKR1C1 (0.47) | HDAC4HSD11B1AKR1C1 | |
| SCHEMBL501923 | 0.75 | AKR1C1 (0.57) | HDAC4HSD11B1THRBHDAC1HTT | |
| SCHEMBL8572144 | 0.74 | HDAC4 (0.59) | HDAC4ALDH1A1HSD11B1THRBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426108-B1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC (CA) | 2016-08-10 | — | — | EP | disclosed |